pill identifier hydrocodone 325 mg 15 mg adderall rx focalin 10 mg vs adderall and pregnancy how long codeine stays in urine pill identifier 30 mg adderall dosage pastillas alprazolam 0.5 mg safercolon and garcinia cambogia promethazine and codeine syrup uk i want to buy some valium is methadone in tramadol what is the brand name for ambien can i buy codeine in bali reventa 10 mg hydrocodone where to buy phentermine over the counter tramadol hcl 50 mg 58 phentermine 30 mg images bula ritalina la 40 mg of adderall hydrocodone build up in body soma australia xanax off brand names cheapest guaranteed hydrocodone how long does adipex stay in my system hydrocodone 7 5 mg acetaminophen emcyt 140 mg adderall does fastin have phentermine in it walmart pure health garcinia cambogia reviews aura soma ireland side effects of adipex p 37.5 mg atarax 25 mg alprazolam what over the counter drug is equivalent to ambien highest codeine over the counter australia 15 mg adderall capsule street value of adderall 20 mg what is garcinia cambogia fruit called in hindi garcinia cambogia extract walmart price can you cut a ambien cr in half shire brand adderall ir 20mg 100mg adderall ir generic bula do remedio dalmadorm 30 mg adderall who manufactures brand name adderall ir 10mg tramadol biogaran 50 mg tramadol 400 mg high notice tramadol biogaran 50 mg solubility of codeine phosphate in chloroform ibuprofen codeine over the counter phentermine hcl 37.5 mg where to buy imidacloprid generic brands for adderall hydroxycitric acid in garcinia cambogia dr oz what is soma in the cns dextroamphetamine sulfate 5 mg m amphet salts 25 mg vs adderall xr adderall name in mexico tramadol 50mg generic for ultram 180 tablets atomoxetine hydrochloride 18 mg adderall does valium show up in a 5 panel drug test hydrocodone fibromyalgia online buy hydrocodone homatropine syrup kids medicamentos genericos tramadol does liquid codeine make you tired online pharmacy adderall generic cost codeine phosphate overdose mg doctors who prescribe phentermine in northern va qualitest xanax review ativan best for anxiety thuoc elton tab 50 mg adderall how much tylenol in hydrocodone dosages for tramadol in dogs phentermine doctors in raleigh nc hydrocodone in costa rica 200 mg tramadol first time pure garcinia cambogia purchase doctors in little rock that prescribe adipex natural garcinia cambogia results from real people how to dip blunts in codeine ambien in argentina xanax brand name cost alza 36 mg vs adderall overdose 1 mg xanax equals valium time release adderall 25 mg xanax show up in a urine test buy hydrocodone tjuana ibuprofen 600 mg tablets vs hydrocodone what is the best way to get high off ambien does ativan have sulfa in it hydrocodone have codine in it mexico online pharmacy adderall prescription dexamfetaminesulfaat 10 mg hydrocodone buying xanax online canada how long do xanax stay in your blood where can i buy xanax in bangkok 30 mg hydrocodone recreational dose seradep 10 mg adderall what is the work of tramadol in human body does zutripro have codeine in it klonopin 0.5 mg side effects adderall 20 mg recommended dosage buying xanax off craigslist can you snort alprazolam 1 mg how long does 35 mg adderall lasting fda takes hydrocodone off the market codeine in ua 20 mg adderall value chain cimetropium bromide tablets 50 mg adderall is dilaudid in the codeine family garcinia cambogia gold testimonials real estate how long tramadol stay in ur system treximet and adderall online diflucan over the counter substitute for adderall b 973 adderall reviews by patients how long does xanax show up in a urine test 21 mg of hydrocodone ibuprofen and codeine tablets uk lexomil alprazolam biogaran 0.25 mg 10 500 mg hydrocodone price lyrica 150 mg withdrawal from hydrocodone how much weight can i lose on adipex in 3 months zolpidem 10 mg biogaran ativan personality disorder 20 mg adderall xr cant sleep love pure garcinia cambogia extract capsules reviews what mg is green xanax bar order canadian adderall tramadol hcl 50 mg drug test how long does 10mg xanax stay in your urine garcinia cambogia premium extract reviews 35 mg of ambien codeine pills usa can ambien cause metallic taste in mouth buy hydrocodone no prescription no membership europenizare dextroamphetamine codeine and promethazine buy online no rx online pharmacy hydrocodone took 2.5 mg klonopin myorisan generic adderall is ambien available over the counter in mexico is codeine otc in france tramadol legal in uk hydrocodone generic form of vicodin vs percocet half life of codeine in urine gabapentin different mg of adderall phentermine hcl 30mg generic capsule how much xanax is safe to take at once cut tramadol 50 mg in half rsa mlv 3064 adderall real garcinia cambogia brands generic klonopin vs brand name where can i buy garcinia cambogia pills in south africa ultram 50 mg strength art in a manipuri actress soma 100 mg hydrocodone high vs oxycodone time release adderall 20 mg how long does it last white dianabol tablets 10 mg adderall half life of alprazolam in dogs 85 mg hydrocodone what is codeine called in america klonopin next day delivery phentermine 37.5 mg tablet reviews tramadol capsules 50 mg spc is possession of xanax a felony in sc whats generic for codeine adderall time release 30 mg highest codeine over counter uk valium 10 mg wikipedia can i get phentermine at walmart safe amount of tramadol to take 1.5 mg of xanax a day dextroamphetamine purchase online aureomycine 10 mg adderall klonopin in deutschland 18 mg concerta vs adderall xr 6 buy soma buying tramadol in the uk adderall 30 mg orange tablet medication buy msj valium uk alprazolam side effects in pregnancy ambien 10 mg recreational use safe dosage for ultram phentermine in brazil amphetamine salts 20 mg tablet ingredients in red carprieve 20 mg adderall buy valium next day delivery codeine phosphate 30 mg for dogs does phentermine have a diuretic in it brave new world soma definition in psychology donde comprar phentermine 37.5 what are the ingredients in klonopin soma review giant bomb premium dynamic pure garcinia cambogia extract reviews arcoxia etoricoxib 90 mg adderall is it safe to take half an ambien a luat cineva xanax in sarcina tramadol 100 mg liquid alprazolam gocce in acqua vinci soma hotel madrid reviews on garcinia xanax otc canada b 973 adderall reviews by patients xtrememac soma bt walmart phentermine in orlando fl side effects from tramadol in dogs is ambien a controlled substance in new york matriz forma generic adderall vitadone generic adderall medicina tramadol hcl 50 mg difference in fastin and phentermine valium prescription australia vinci soma madrid reviews of windows bestie da soma teofilo patini prints soma books uk tramadol 50 mg presentacion questran over the counter alternative to hydrocodone hydrocodone mg apap 5 500 tab xanax 20 mg overdose is there an over the counter form of adipex buy alprazolam powder online phentermine 37.5 mg tablets canada generic adderall vs brand buy hydrocodone without 20 mg adderall ir twice a day bid restoril vs ambien sleep disorders soma 350 mg medication soma seeds uk buy xanax bars street cost which states is codeine over the counter se necesita receta medica para comprar valium does xanax come in liquid 8 mg iv dilaudid high vs hydrocodone soma review steam 10 mg adderall pills pic xanax dosage australia 400 mg codeine equivalent lean body garcinia cambogia review soma 1400 mg natures bounty xanax time in system drug test no online prescription soma highest mg of adderall xr buy phentermine in los angeles carisoprodol online qoclick buy phentermine tablets online ritalin or adderall for sale does adderall show in drug test promethazine codeine in australia price of generic valium can i buy ativan online street name for hydrocodone acetaminophen 5 500 generic codeine 600 mg valium gocce vendita online diazepam 10mg buy how long does klonopin stay in your system if snorted 30 mg adderall generic does tramadol reduce fever in dogs deprexolet 30 mg adderall best codeine pills tramadol side effects in elderly weight gain in xanax etodolac 500 mg vs hydrocodone oxycodone doctor on demand adderall online weather in abu soma egypt 75 mg adderall high heart essential source hca garcinia cambogia reviews hydrocodone not detected in 5 panel test is soma a narcotic in tennessee slimera garcinia cambogia price paxil 20mg to 10 mg adderall where can you buy phentermine online ativan overdose 15 mg my psychiatrist wont prescribe me adderall generic al soma all cards in standard what is the function of tramadol in the body order tramadol over the phone length of time valium stays in urine tramadol use in first trimester list of generic adderall names cbd 50 mg adderall bula frisium 20 mg adderall doctors in oklahoma city who prescribe xanax how long does xanax stay in your system 2mg ingredients in garcinia cambogia for real klonopin 1mg generic tramadol 50 mg im cheap bulk valium 120 mg codeine alcohol trazodone 50 mg vs ambien soma pills high in estrogen tramadol mylan 200 mg safest way to get off klonopin effects of .50 mg xanax hysingla generic adderall can i take 4 .25 mg of xanax boots chemist codeine soma hair care salons in phx strattera weight loss vs adderall generic can you buy codeine over counter uk ambien cr 6.25 mg reviews loren 10 mg adderall cambogia garcinia extract ukiah valium 5mg kaufen fioricet with codeine 30 mg xanax in new jersey cheapest vetoryl capsules 60mg hydrocodone best antidepressant adderall generic names for adipex garcinia cambogia real vs fake timberland green klonopin mg teva san francisco apartments for sale soma blue capsule generic adderall prices provigil 500 mg what does generic valium look like codeine phosphate in early pregnancy tramadol 50 mg ndc drug test for adderall prescription in ohio is tramadol controlled in pennsylvania dan brand soma online preis valium 10 mg over the counter klonopin fluxene cloridrato fluoxetina 10 mg adderall cheap klonopin overnight delivery gia thuoc papaverine 40 mg adderall best way to crush up xanax cheap overnight phentermine buy soma usa where can i buy garcinia cambogia extract walgreens generic valium not as good can you get high off 200 mg tramadol will klonopin show up in urine test the best way to take a xanax soma coma seeds for sale buy garcinia cambogia extract malaysia what is generic for valium phentermine buy online usa soma pareti divisorie in legno fioricet with codeine brand name xanax 1 mg prezzo 10 mg adderall dangerous 20 mg orange adderall pill 36 zolpidem al 5 mg nebenwirkungen actavis 30 mg adderall safe to take xanax day after drinking adderall xr vs adderall generic name buy phentermine online new zealand soma 10 mg alprazolam withdrawal in dogs is baclofen generic for soma 10 mg adderall high feeling how many milligrams of codeine in cheratussin how many mg of adderall is too much phentermine in norman ok phentermine in san antonio tx street cost for tramadol 20 mg adderall orange capsule 30mg ambien over the counter in canada core pharma adderall reviews from moms buy cheap xanax australia xanax sale online la garcinia cambogia produce diarrhea in cats valium 10 mg cpr buy garcinia cambogia online india soma de pge pay bill in person xanax off the market adderall uk name for chips zolpidem in persistent vegetative state problems with generic adderall can you buy valium in south america price of adipex at walmart garcinia cambogia fit 1300 estas price best way to come off ativan soma meaning in sanskrit does adderall xr have a generic legal xanax online pink 15 mg adderall 30 mg adderall time release duration of cold verdun 50 mg adderall hydrocodone apap safe dosage is 10mg of ambien safe zolpidem 5 mg not working 325 mg acetaminophen 5 mg hydrocodone ambien pills online soma 350 mg vs flexeril 10mg dosing different mg of zolpidem what is zolpidem tartrate generic for soma bringer review ign behind the counter codeine cough syrup 2 generic soma united states ambien price canada xtreme garcinia cambogia 1500 mg 60 hca soma in carrollton ga codeine promethazine cough syrup uk is it safe to take ultram with suboxone how long will codeine show up in a blood test is phentermine safe while trying to get pregnant addicted to codeine uk generic for adderall medication precio tramadol edigen 50 mg ultram highest mg of hydrocodone imigran generic is taking ambien while pregnant safe comprar prazol 30 mg hydrocodone adderall xr 25 mg twice a day 2mg alprazolam price klonopin buy uk prednisone 5 mg withdrawal from hydrocodone what mgs does tramadol come in tylenol with codeine in elderly liquid adderall adhd how many mg of klonopin is equal to xanax thuoc prazepam 10 mg adderall how long does a xanax stay in your system for drug test super pure garcinia cambogia reviews ultram vs tramadol generic best diet to go with garcinia cambogia how much weight can i lose on phentermine in 6 months tramadol in pregnancy nhs ultram cost at walmart tramadol reviews for pain villa soma jimbaran reviews phytogenix laboratories garcinia cambogia reviews oxyneo 10 mg adderall best way to order xanax online shokugeki no soma recipes real food order dextroamphetamine on line no persriptions bernard lagat 1500 mg garcinia cambogia how many mg of ultram can i take klonopin safe alternatives necon 1 50 generic adderall garcinia cambogia where to buy gnc is codeine in lortab ultram 50 mg walmart vyvanse 50 mg vs adderall coupons alprazolam brand names in australia how many mg is a xanax blue football 15 mg adderall effects in adults difference in zolpidem and zolpidem tartrate rightway nutrition 100 pure garcinia cambogia reviews dose of tramadol in rats how long xanax stay in your system drug test price check generic adderall side can you get pure garcinia cambogia at walmart can you cut ambien pills in half most reputable company to buy garcinia cambogia true cambogia garcinia reviews can you buy tylenol with codeine online tramadol in combinatie met alcohol generic adderall xr blue pill buy adderall xr online without script mezolium 40 mg adderall 7 5 mg liquid hydrocodone pure garcinia cambogia nz stockists in dublin hoavb org 4 cheap soma counter adderall vasoconstriction definition promethazine codeine syrup online pharmacy tramadol hydrochloride 250 mg alprazolam eg 0.50 mg how long does adderall last 5 mg masterchef 3 enrica soma artesiane 40 mg of adderall xanax .5 street price garcinia cambogia slim reviews can a 50 mg tramadol get you high citalopram weight loss 20 mg adderall can you snort alprazolam 1 mg effective garcinia cambogia brand philippines embassy can you get phentermine in australia garcinia cambogia price in pakistan mobile aptamil avec pro nutra garcinia cambogia reviews gnc over the counter pain meds with codeine best effect from adderall ativan in elderly dosage 80 mg hydrocodone too much legal buy adderall online 7 5mg liquid hydrocodone acetaminophen neo mercazole 20 mg adderall anxiety disorders medication xanax 30 mg codeine compared to 10mg hydrocodone street difference between generic and brand name adderall cost codeine cough syrup manufacturer in baddi how to pass a urine test with xanax in your system blue capsule adderall mgs 30 mg hydrocodone medicine effexor 37 5 mg withdrawal from hydrocodone phentermine diet pills 30 mg codeine australia buy can tramadol cause side effects in dogs adderall ir 15 mg duration generic adderall contents of the ark codeine cough syrup where to buy trasicor 80 mg adderall is valium available over the counter in france how long does one dose of xanax stay in your system 2.5 mg xanax at once what class is tramadol uk ceva carprodyl 50 mg adderall when is the best time of day to take klonopin tramadol in cancer pain hydrocodone 10 mg apap 325 mg garcinia cambogia real products 10 mg hydrocodone yellow eyes side effects garcinia cambogia uk stockists is tramadol a controlled substance in maine does chlorzoxazone have codeine in it bilocor 10 mg adderall xanax online from canada A national neonatal screening programme for hemoglobinopathies in the Netherlands Hospital devices Medical devices

A national neonatal screening programme for hemoglobinopathies in the Netherlands

Figure 1. HPLC result of a healthy newborn with ≈80% HbF and ≈20% HbA.
Figure 2. HPLC result indicating sickle cell disease either by homozygote HbS or by compound heterozygote HbS/β-thalassemia.
Figure 3. HPLC result indicating an HbS carrier.
Figure 4. HPLC result indicating HbH disease.
Table 1. Results of pilot study and nationwide screening in 2007 and 2008.

On 1 January 2007 neonatal screening for sickle cell disease commenced in the Netherlands. This implementation was preceded by a pilot study in two of the five Dutch screening laboratories. During this pilot study 21,969 dried blood spots from the regular neonatal screening programme were analysed for hemoglobinopathies. In the first two years (2007-2008) of nationwide screening, 83 children with presumed sickle cell disease and four children with b-thalassemia major were referred to a pediatrician. During these two years 82 children were also referred because of screening results indicating hemoglobin H (HbH) disease. The referred children benefited from screening because it allowed early treatment, which reduced complications.

by Dr M. J. Bouva and Dr B. Elvers

Sickle cell disease (SCD), β-thalassemia major (βTM) and hemoglobin H (HbH) disease are hemoglobinopathies with intermediate or severe pathology. Some of the patients with the most severe disease can be cured by bone marrow transplantation, but for most patients treatment consists of transfusion/chelation therapy, pain relief and management of the complications, such as organ damage in the case of sickle cell disease.

The World Health Organisation has estimated that each year over 330,000 babies are born worldwide with a severe form of hemoglobinopathy [1]. Early detection of sickle cell patients for instance, allows treatment with antibiotic prophylaxis to prevent life-threatening complications from Streptococcal pneumonia.

As well as preconceptional and prenatal screening for hemoglobinopathies, neonatal screening using iso-electrofocusing (IEF), electrophoresis, high performance liquid chromatography (HPLC) and mass spectrometry (MS) is being performed in an increasing number of countries, such as the United States [2], United Kingdom [3, 4] and France [5]. In 2005 the Dutch Minister of Health decided to expand the national neonatal screening programme to cover seventeen diseases (previously three) including screening for sickle cell disease. After a pilot screening study [6], nationwide screening started in January 2007 using the Bio-Rad Variant Newborn Screening (Vnbs). This article summarises the results of the pilot study and reports on the results of the screening programme in the first two years.

The Variant Newborn Screening (Vnbs) is a cation exchange HPLC-method. A three mm punch from a dried blood spot is extracted in 230 µL deionised water in a well of a microtitration plate. Normal blood (pattern FA) in a newborn consists of about 80% fetal hemoglobin (F) and 20% adult hemoglobin (A) [Figure 1]. A newborn with sickle cell disease produces hemoglobin S instead of A (pattern FS) while an HbS carrier produces both F, A and S (pattern FAS). [Figures 2 and 3]. All HPLC patterns from neonates also have a small first peak, called the FAST-peak, which mainly consists of degradation material. Children with alpha-thalassemia also produce HbBart’s and this HbBart’s appears in the FAST-peak [Figure 4]. Children with a FAST-peak ≥ 20% are also referred to the pediatrician for suspected HbH disease.

Pilot study
Between March and June 2006 a pilot study was performed in the laboratories of the IJsselland Hospital in Capelle aan den IJssel and the National Institute for Public Health and the Environment in Bilthoven (RIVM), The Netherlands. A total of 21,969 random dried blood samples (DBS) from the regular neonatal screening programme were analysed on the Vnbs. Parents had given their consent to use the spots for anonymous scientific research purposes. The HPLC results indicated three sickle cell disease (SCD) patients, two β-thalassemia major (βTM) patients and 83 carriers of sickle cell disease [6].

From this pilot study, it became clear that the method of integration of the HPLC pattern was not always consistent. ‘Valley to valley’ integration and ‘drop–line’ integration were used alternately. This prevented the assessment of normal values in relation to gestational age (see discussion).

Nationwide screening in 2007 and 2008
Neonatal screening in the Netherlands is a nationwide programme carried out by five screening laboratories, with the RIVM in Bilthoven being the reference laboratory. This screening programme has a compliance of 99.5%, and the birth rate is around 185.000 children per year. Between 72 and 168 hours after birth a heel prick is performed and blood is collected on filter paper and sent to the regional laboratory. Commencing on 1 January 2007, all dried blood spots (DBS) were analysed on the Vnbs HPLC system. Children with screening results indicating SCD, βTM and HbH disease are referred to a pediatrician for confirmation and treatment. Parents of the affected children are guided by a genetic counsellor. These parents are informed about their own carrier status and the consequences, and educated to deal with the complications of their child’s disease.

Carriers of HbS are reported to the general practitioner. Parents of these carriers are advised to have their own carrier status determined. If both parents are carriers, the neonatal screening programme can thus also help prevent subsequent children being born with a hemoglobinopathy.

In the first year of screening for hemoglobinopathies (2007; 182,302 newborns) 41 children were referred with suspected SCD. In two cases the HPLC results indicated a βTM, but at least two children with βTM were not referred because the HPLC result only detected a small amount of HbA. Nineteen children were presumed to have HbH disease because of a high HbBart’s concentration (≥20%). Of all screened children, 0.441% (805) were informed about their HbS carrier status.

In 2008 187,075 children were screened, 32 children were referred to the pediatrician for confirmation of SCD, two children for βTM and 62 for HbH disease.

Prior to the implementation of neonatal screening for sickle cell disease a pilot screening study was performed by the RIVM and IJsselland Hospital. Based on the results of this pilot study, Bio-Rad was convinced to adjust its integration software. This resulted in a more reliable determination of the peak percentages. Because of this the Bio-Rad Vnbs HPLC system, which was in principle developed to screen for SCD only, also became a potential candidate method for screening for thalassemia [6].

Based on the results of the pilot screening study, it was expected that each year 40 to 50 newborns with SCD or βTM would be born in the Netherlands. Furthermore, around 1200 carriers of one of the most prevalent hemoglobin variants (HbS, HbC, HbD-Los Angeles and HbE) were expected [6]. These figures were confirmed by the results of screening in 2007 and 2008 [Table 1].

The primary goal of the Dutch screening programme was to detect children with sickle cell disease and provide them with early treatment. Because the HPLC technique also detects other variants besides HbS, the screening programme was able to report all clinically relevant diseases (βTM and HbH disease) and carriers of HbS. For the screening of βTM and HbH disease cut off values were necessary. Children with no HbA and only HbF were putatively reported as βTM patients. When the HPLC showed an HbBart’s peak ≥ 20%, the newborn was referred for HbH disease. Within the first year of screening at least two children with βTM were not referred to the pediatrician because they showed traces of HbA. To improve screening of βTM, a cut-off value was set for HbA after some scrutiny of results. Starting on April 2009, all children with less than 1.0% HbA were referred. Furthermore, all children of at least 32 weeks gestational age and with 2.5% HbA or less were also referred.

In 2008 a significant increase in number of referrals for HbH disease was noticed. In part this was caused by a new resin used in the Vnbs. Because the system was developed to detect hemoglobin variants such as HbS, the resin was not tested for accuracy of detection of HbBart’s. This problem was quickly solved by Bio-Rad. However, most of the children referred for HbH disease were diagnosed with a mild alpha-thalassemia. Starting on January 2010, the cut off value for HbBart’s to detect HbH disease was raised to 22.5%, hopefully resulting in less referrals and higher true positive rate.

In the near future the target of the screening programme will be changed, from screening for SCD only to screening for SCD and βTM. HbH disease and carriers of HbS will still be reported, and probably carriers of the other hemoglobinopathies will also be reported to the general practitioner.

We thank the screening laboratories (Dr A. Boelen, Academical Medical Center, Amsterdam; Dr E.A. Kemper-Proper, IJsselland Hospital, Capelle a/d IJssel; Dr R. Triepels; Elisabeth Hospital, Tilburg; Dr J.M.M. Rondeel. Isala clinics, Zwolle) and Dr M. Peters (Advisory Committee on Neonatal Screening for Sickle Cell Disease) for their contribution in the screening and Dr JG Loeber RIVM for helpful discussions.

1. Modell B and Darlison M. Global epidemiology of haemoglobin disorders and derived service indicators. Bulletin of the World Health Organisation 2008;86.
2. Benson JM and Therrell BL, Jr. History and current status of newborn screening for hemoglobinopathies. Semin Perinatol 2010;34:134-44.
3. Streetly A, Clarke M, Downing M et al. Implementation of the newborn screening programme for sickle cell disease in England: results for 2003-2005. J Med Screen 2008;15:9-13.
4. Streetly A, Latinovic R, Hall K and Henthorn J. Implementation of universal newborn bloodspot screening for sickle cell disease and other clinically significant haemoglobinopathies in England: screening results for 2005-7. J Clin Pathol 2009;62:26-30.
5. Bardakdjian-Michau J, Bahuau M, Hurtrel D et al. Neonatal screening for sickle cell disease in France. J Clin Pathol 2009;62:31-3.
6. Bouva MJ, Mohrmann K, Brinkman HB et al. Implementing neonatal screening for haemoglobinopathies in the Netherlands. J Med Screen 2010;17:58-65.

The authors
Dr MJ Bouva and Dr B Elvers
National Institute for Public Healh and the Environment,
Laboratory for Infectious Diseases and Perinatal Screening,
The Netherlands
e-mail: marelle.bouva@rivm.nl


Contact form

Get in touch directly with the above supplier

Pre-fill this form automatically in My CLI

Last name:*
Job title:*
Postal Code:*
Email (confirm):*
Your email address will not be communicated to any third party other than the above supplier for the purpose of fulfilling this enquiry. For more information: CLI's privacy policy
Send product data
Send price data
Send dealer data
  I would like to receive CLI's electronic publications

CLI :: Your advertise here !

Alternative content

Get Adobe Flash player

Sponsored links: