New technology platform for molecular diagnostics
Molecular diagnostics
A fully automated microarray technology platform has been developed, with associated multiplex tests, for clinical molecular diagnostics.
Anagnostics’ “hybcell” technology is based upon the use of two concentric cylinders. Detector molecules are immobilised on the surface of the inner cylinder in a microarray format and the cylinder is placed inside the outer, transparent cylindrical container. Both cylinders fit snugly together and represent the core of the hybcell. Sample is pipetted into the hybcell via the axial (central) channel and the cartridge is closed and then transferred to the actual operational device (hyborg), which from then on takes over and, fully automatically, carries out all remaining steps. The hyborg unit can be loaded with 8 or 96 hybcells. The controlling software is simple and intuitive so the system is well suited for clinical diagnostics. The first application of the new technology platform is for antibody-based tests of drugs of abuse using saliva as test sample. As little as 1ng drug per mL saliva can be detected using the system. The test has been validated by independent experts.
The second application of the technology is a DNA-based test for the rapid detection of pathogens involved in sepsis. About to undergo validation, this test system is aimed at the identification of a wide spectrum of pathogens and the determination of their antibiotic susceptibility and resistance within three hours, so that appropriate therapy can be initiated as rapidly as possible.
Anagnostics Bioanalysis
St Valentin, Austria
Anagnostics Bioanalysis GmbH
