Telomeres and Telomerase in Cancer
Book review
Book review
Edited by Hiyama, Keiko. Published by Humana Press, 2009, 380pp, €119,95.
Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalisation. Telomere shortening due to “end-replication problem” in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also common from yeast to humans. However, the length of telomeres, distribution of telomerase positive cells and consequence of telomerase inhibition are different among species. In this book, one of the “Cancer Drug Discovery and Development” series, the focus is on human telomeres and telomerase, from basic biology and hypotheses in normal human cells and cancer cells to clinical applications for diagnostic tools and therapeutic targets in anti-cancer strategy. Cutting-edge experimental protocols for their evaluation are also included. This book captures the up-to-date entire picture of human telomeres and telomerase in cancer.
Humana Press Inc
